Hi and welcome to the forum 
I do not use Wine myself, but found the similar question in Ubuntu forum (Zorin is based on Ubuntu, Playonlinux is essentially the same as Wine)
The first answer:
AFAIK, Wine does not support USB drivers, so you can't connect any USB device to Wine/PlayOnLinux, but Wine does support serial devices, including serial over USB. Check if your device is being recognised as a serial device, e.g.
/dev/ttyUSB0. If true, you can create a symbolic link between/dev/ttyUSB0and wine dos device file located in~/.wine/dosdevices/