Hi, in the house is a CanoScan LiDE 500F, never supported on GNU/Linux. I installed PCLinuxOS (rpm version) and Skanlite (a KDE app) got it working instantly! There are some Xsane backports and I never quite understood how to implement them. All I can say is, if you haven'd done so already, install Synaptic Package Manager from Software or via the terminal with:
sudo apt install synaptic
Once installed, click on search button and in the search field that apppears, enter skanlite:
If this still does not work, the solution is a proprietary one which offers a more professional interface than what any Canon Scangear can offer and that is
VueScan (you can download a demo to see if it will work) from here:
I purchased the Professional licence which lasts a lifetime and you get free updates when they come out.