Can you please outline the steps you took and what message the system gave?
Commenting out, in this case, means placing a hashtag on front of the line. A hashtag tells the system to Ignore That Line.
For example:
This line is read and adhered to by the system
#This line is exactly like the one above, but ignored by the system.
It's already got ### in front of it. You want 4 or 1?
1 is all you need... but if it is Already Commented out- then that venture is pointless.
Let's try looking at something else...
sudo nano /etc/modprobe.d/alsa-base.conf
Look for this line:
options snd-hda-intel power_save=0
If it is not there, then paste it in at the end of the file (Move to the end using arrow keys).
Then ctrl+x to exit, y to sya yes to save, then enter to save and exit.
I am not allowed to edit alsa-base.conf.
Apparently, I'm "not the owner" of this PC.
That script was supposed to edit it but didn't.
Ownership of files...
What Message did the System Display?
File is read only and I am not allowed to change.
Is Root the owner?
Try
sudo -i
To elevate to Root. If need be, you can change the file access from read only to read /write. Any of:
chmod 666 /etc/modprobe.d/alsa-base.conf
echo 'options snd-hda-intel model=mbp55' >> /etc/modprobe.d/alsa-base.conf
chmod 644 /etc/modprobe.d/alsa-base.conf
Operation not permitted, access denied. On all three.
How odd... Did you set up a different user account when you installed Zorin OS?
No but I did change my user name but changed it back.
Edit: Took control of file using sudo -H nautilus. But the script did not add the line. Gonna try to add it manually but that guy's site is down. Might be:
options snd-hda-intel power_save=0 power_save_controller=N
What else can go wrong?
Edit: SUCCESS.
By why did I have so much trouble doing these things when others didn't? I'd better keep sudo -H nautilus handy.
What I learned:
*Do NOT change your user name
*To run a script (at least my way), paste it into a text file, trim junk off the top, change extension to sh, click the file and run in terminal, put in your password (terminal does not show you what's happening tho, might flash)
You can wrestle control of a file with sudo -H nautilus, which opens a browser where you can locate the file
Another thing which MAY have caused this prob is I turned off Suspend When Laptop Lid is Closed (I have a desktop). This may have sent a signal that I am on a laptop and turned on audio power savings.
Update: Booted from the thumb drive and the popping sound is there! The default for Zorin is to idle the sound after 10 secs. Doesn't the popping on resume bother anyone else?
I never experience it- which suggests it is specific to your machine or hardware.
OK, guess that's it. The odd thing is, I used it for two weeks and never paid attention to the these very obvious sounds. 
If it was not doing so, then began doing so... I would suspect an update brought the change. Perhaps kernel, perhaps driver, perhaps peripheral code that affects it...
In my own experience... When an update brings a bug, it usually is resolved in the next update, due to bug reporting.
But we can try things like rolling back the kernel or checking your drivers.
Can't be it, I booted from the thumb drive. Unless that gets updated.
Maybe we just don't notice things until we do?
I am notorious about this... 
It only can be updated if run with persistence...
Anyway, I am now enjoying the silence. And I learned how to edit a file using sudo -i nautilus. Also run a script.
This seems to fix it, unfortunately on my connected headphones at the airport, can't test until I get to my destination later. I'll let you know if this fixes it later today.
Thanks again.
Just following up on this proposed fix to disable/comment out:
load-module module-suspend-on-idle
worked for me. Thanks again.
New issue. I locked the laptop and stepped away to shower, came back out to use the laptop, started Spotify and got no sound. so popping noise definitely went away, but losing sound altogether makes it worse. Any ideas on this?