Very nice! Better living when you can see what you are doing! 
The only game i still can't get to work is Star Trek Starfleet Command III. Tried everything, followed the instructions from the lutris site...nothing works. Using the gog version.
Whats abnormal is its trying to use Windows garbage! But looks like a C++ issue regardless. I stopped trying to install games via disk years ago, I completely converted over to Steam only. And one of the reasons why, is because I never could get any game to work in Wine.
Hopefully, you get this GOG game fixed.
Yeah, even with C++ installed does not fix the problem. I know steam fixes everything for windows just by using proton. But i want to understand why this problem is not fixed under lutris and what it needs to get it running haha.
Thanks for this tip. Was looking at a different guide on this, but nothing really made sense to me. Something about putting this into the .var folder. Also it suggested adding a Wine package. Due to not wanting to mess around with the OS itself too much and break something, I chose to stop.
But this worked great for me.
Also I am new to ZorinOS. Loving 16 so far.
I am loving your avatar too! I am glad the new PROTON is working for you. Wine is just too difficult to manage for most of us. Michel became king of it overnight, don't ask me how, but he dominated that software and made it his, you know what lol.
Welcome To Zorin OS 16 BTW, happy to have you hear and enjoying the OS.
Thanks for the welcome. Proton was the final step for me to move over to Linux as my daily driver. It's almost there, and I think the Steam Deck will be the turning point up next.
I tried a few other distro's this week, but Zorin was the only one that worked fine out of the box. Not sure why. But I'm here and enjoying it. Def. gonna recommend it for Windows users looking for an option.
Hi TCi, for the official builds in steam just use the search function in steam and write proton. You get a list which proton versions you can download. The ge versions are custom builds with alot of fixes that are not included yet in the steam proton.
Just an update. While Back 4 Blood starts and works fine in the lobby, it does not work in a party in campaign.
I guess I will have to be a bit more patient for a future update.
Does that game use anti cheat ? If yes that might be the problem
Edit:
That is correct. It worked before, and this custom version resolved most of the issues, but sadly not the main issue. My bad for jumping to thinking it was fine.
Proton-6.20-GE-1 Released
-wine: Added fix for broken right click camera control in BeamNG.drive
-wine: Revert some upstream commits to re-allow mfplat patches (it was disabled in wine-staging 6.20 due to patches needing a rebase)
-wine: Add patch to fix Eve online launcher (thanks Tr4sk!)
-wine: Add patch to workaround The Good Life video playback (thanks popsUlfr!)
-wine: Add patch to fix Castlevania Advance Collection and a few other Konami "collection" games (thanks Raptor85!)
-wine: rebased proton patches for 6.20
-wine: updated to 6.20
-protonfixes: Added vcrun2019 to Injustice 2 -- fixes multiplayer desync
-protonfixes: Removed no-longer needed .NET installation from Batman Arkham Asylum protonfix (allows it to work again)
-protonfixes: Added xaudio3_7 protonfix for Resident Evil 4 (fixes crash on loading from save)
-protonfixes: Removed no-longer needed xlive override for Fallout 3 (thanks manueliglesiasgarcia!)
-protonfixes: Added workaround that uses Proton 5.0 to install .NET into the prefix for Space Engineers (.NET installation is broken on wine 6.0+, thanks manueliglesiasgarcia! )
-protonfixes: Added vcrun2019 to Madden NFL 21 -- fixes multiplayer desync (thanks Alexithymia2014!)
-protonfixes: Gothic2: account for varying casing in game paths (thanks codicodi!)
-protonfixes: Uplay overlay disabled for Assassin's Creed: Odyssey (thanks PolisanTheEasyNick!)
-protonfixes: mfc42 override added for GT Legends (thanks otokawa-mon!)
-proton-valve: Imported fixes for paradox launcher from proton upstream
-proton-valve: Imported fixes for Nickelodeon All-Star brawl from proton upstream
-proton-valve: Imported fixes for WRC8/9/10 from proton upstream
-proton-valve: Imported fixes for Satisfactory multiplayer from proton upstream
-proton-valve: Imported fixes for Fallout 76 crash from proton upstream
-vkd3d-proton: Update to git
-vkd3d-proton: DXR 1.1 is now experimentally exposed. It can be enabled with VKD3D_CONFIG=dxr11.
-vkd3d-proton: Resizable bar now enabled automatically if available. NOTE: You may need to disable this in eGPU setups to avoid performance issues: VKD3D_CONFIG=no_upload_hvv
-vkd3d-proton: Marvel's Avengers now playable (again)
-dxvk: Update to git
-faudio: Update to git
Nice, will update it asap 
I wonder how you can enable settings like these in steam.
Steam allows opening of games via launch commands. If you right click the game, go to properties. You will find a launch command box. But that box shares a quality that terminal has. All spelling and syntax must be 100% correct.
You can find Steam launch commands from a Google search. From there you can learn what commands you can do, and how to input them properly. But yes, you can launch games with certain commands, like telling it to only use DirectX 11 or 10 or 9.
Thanks will look into that. Sadly for custom added games those options are not available 
-wine: Added fix for broken right click camera control in BeamNG.drive
-wine: Revert some upstream commits to re-allow mfplat patches (it was disabled in wine-staging 6.20 due to patches needing a rebase)
-wine: Add patch to fix Eve online launcher (thanks Tr4sk!)
-wine: Add patch to workaround The Good Life video playback (thanks popsUlfr!)
-wine: Add patch to fix Castlevania Advance Collection and a few other Konami "collection" games (thanks Raptor85!)
-wine: rebased proton patches for 6.20
-wine: updated to 6.20
-proton-valve: Imported fixes for paradox launcher from proton upstream
-proton-valve: Imported fixes for Nickelodeon All-Star brawl from proton upstream
-proton-valve: Imported fixes for WRC8/9/10 from proton upstream
-proton-valve: Imported fixes for Satisfactory multiplayer from proton upstream
-proton-valve: Imported fixes for Fallout 76 crash from proton upstream
Download can be found below:
@Michel is best specialist how to working games on Linux this forum with 1 place I bet. I know another people here also know how to figure to working a games but @Michel have a huge library a games what working on Linux. 
Wine-6.21-GE-1 released
-Proton BattlEye patches added -- Currently this is not relevant for non-steam games, but may be useful in the future (unknown)
-Proton Forza Horizon 5 patches added
-Proton Guardians of the Galaxy patches added
-Proton Fallout76 patches added
-Proton Baldur's Gate 3 patches added
-Proton Age of Empires IV driver nag fix patch added
-Proton fsync patches updated to futex_waitv version
-Fix for error when using file browser to pick a file location added (this occurred usually in applications when you tried to specify an existing file location -- notably in Battle.net)
-Fix for broken mouse input in Borderlands and R6S added (was not present in 6.20, issue appeared in 6.21)
-Fix for the beamng mouse issue updated so that it does not affect non-steam games
-Bcrypt patches updated (steep works again, thanks openglfreak!)
-vulkan childwindow patches updated
-wine mono version updated
Notes:
-Fsync can cause Uplay to hang on "Looking for patches" when initiating a new prefix. Esync works fine.
-Various Uplay titles that have a vulkan native mode (Rainbow 6 siege) need the overlay disabled in order not to crash. DX11 mode works fine.
-uplay likes to hang out after the game has closed -- make sure you close it in the task manager.
Download: Release Wine-6.21-GE-1 released · GloriousEggroll/wine-ge-custom · GitHub
Proton-6.21-GE-1 Released
-Proton BattlEye patches added
-Proton CEG patches added
-Proton Forza Horizon 5 patches added
-Proton Guardians of the Galaxy patches added
-Proton Fallout76 patches added
-Proton Baldur's Gate 3 patches added
-Proton Age of Empires IV driver nag fix patch added
-Proton fsync patches updated to futex_waitv version
-Fix for error when using file browser to pick a file location added (this occurred usually in applications when you tried to specify an existing file location)
-Fix for broken mouse input in Borderlands and R6S added (was not present in 6.20, issue appeared in 6.21)
-Fix for the beamng mouse issue updated so that it does not affect non-steam games
-Bcrypt patches updated (steep works again, thanks openglfreak!)
-vulkan childwindow patches updated
-vkd3d Forza Horizon 5 patches added
-vkd3d Guardians of the Galaxy patches added
-vkd3d updated to latest git
-dxvk updated to latest git
-protonfixes uplay overlay disable function has been fixed to apply correctly when used.
-wine mono version updated
-protonfix added for ship graveyard simulator (and prologue, Thanks Alistair Leslie-Hughes!)
Notes:
-Fsync has been disabled on all Uplay titles -- it causes Uplay to hang on "Looking for patches" when initiationg a new prefix. Esync works fine.
-Various Uplay titles that have a vulkan native mode (Rainbow 6 siege) need the overlay disabled in order not to crash. DX11 mode works fine.
-For games that have a protonfix that uses the uplay overlay disable -- if creating a new prefix you will need to relaunch the game a second time. Uplay completely removes any pre-existing configurations on first launch, so any appending to the file gets removed. Upon re-launch the option will be re-appended and uplay will then see it.
-uplay likes to hang out after the game has closed -- make sure you close it in the task manager.
BattlEye games tested and working:
Ark: Survival Evolved
BattlEye games tested and not working:
Mount & Blade: Bannerlord -- hitting this issue: ValveSoftware#3706 (comment)
CEG games tested and working:
Bioshock Infinite
Just Cause 2
Black Ops II Campaign
Sid Meier's Civilization V
Mafia II (Classic)
CEG games tested and not working:
Black Ops II Zombies Mode -- exemption occurs a few seconds after getting to main menu
Black Ops II Multiplayer -- same issue as zombies mode
Warhammer: Space Marine -- bugsplats
Lara Croft and the Guardian of Light -- just hangs in the background infinitely until force killed
Download: Release Proton-6.21-GE-1 Released · GloriousEggroll/proton-ge-custom · GitHub
Proton 6.21-GE-2 Released
This is a hotfix to apply the following important revert from Valve:
Additionally, the release files for Proton-6.21-GE-1 have been removed to aide in further preventing people from accidentally launching Destiny 2 and getting themselves banned, per the above hotfix.
https://github.com/GloriousEggroll/proton-ge-custom/releases/tag/6.21-GE-2