PC won't wake up from sleep using mouse or keyboard, it needs a power button press.
To make it work out of the box would be to follow this arch wiki entry
https://wiki.archlinux.org/title/udev#Waking_from_suspend_with_USB_device
some more info
https://wiki.archlinux.org/title/Power_management#Suspend/resume_service_files
My output when it is NOT working, despite USB shown as enabled.
$ cat /proc/acpi/wakeup
Device S-state Status Sysfs node
PCI0 S5 *disabled no-bus:pci0000:00
PEX0 S5 *disabled pci:0000:00:1c.0
PEX1 S5 *disabled
PEX2 S5 *disabled
PEX3 S5 *disabled
PEX4 S5 *disabled pci:0000:00:1c.4
PEX5 S5 *disabled pci:0000:00:1c.5
HUB0 S5 *disabled pci:0000:00:1e.0
UAR1 S3 *disabled
IGBE S4 *disabled
USB0 S3 *enabled pci:0000:00:1d.0
USB1 S3 *enabled pci:0000:00:1d.1
USB2 S3 *enabled pci:0000:00:1d.2
USB3 S3 *enabled pci:0000:00:1a.0
USB4 S3 *enabled pci:0000:00:1a.1
USB5 S3 *enabled pci:0000:00:1a.2
USBE S3 *enabled pci:0000:00:1d.7
USE2 S3 *enabled pci:0000:00:1a.7
AZAL S5 *disabled pci:0000:00:1b.0