Apparently...
Fuse3 supercedes Fuse.
Fuse is what comes with Zorin OS.
The recent xdg-desktop-portal package update depends on Fuse3, thereby insisting it be installed in order to upgrade xdg-desktop-portal.
This necessitates removing the existing Fuse Package.
Fuse3 can be safely installed and the packages that rely on Fuse can also use Fuse3.
So, you can install or upgrade xdg-desktop-portal and fuse3 safely:
sudo apt install xdg-desktop-portal -y
But It is unsafe to then try removing the Fuse Packages since the Zorin OS Desktop Environment depends on Fuse.
So install/upgrade - and then leave it safely as it is...
Or, Ignore the prompt to Upgrade xdg-desktop-portal...
Or...
Use sudo apt-mark hold xdg-desktop-portal to hold the package at current version and stop the nagging prompts.