Mouse not waking computer

My computer does not like to wake with mouse. After many searches I found;
"sudo nano /sys/bus/usb/devices/usb7/power/wakeup" Choose the proper usb host, change to enable . I do this and it works fine for a while. Seems like maybe a hard reset, something is changing it back to disable! How can this happen? It takes a sudo command for me to change it, but the computer changes it at will!
This is an Asus Rampage III Extreme board.

Thanks for the help

Here are quite a few suggestions you can try to make the change persistent:

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Thanks, looks like more reading

This is one crazy system! The mouse or usb bus is moving! Was 3 now 1

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