No. I've downloaded it for testing and to have it as BackUp if I should need it. But when I installed Pro with the ''first'' ISO, I didn't had Issues either with the Installation.
But that is in Common the Thing: User A doesn't have any Problems but User B does. So, I wouldn't take my experience as a Blueprint.
I have used the live session nearly every day since Zorin 18 has been released and had the most problems with r2 .iso. But maybe it is coincidence or because I had more often Wayland enabled. Long time with the first .iso I didn't upgrade the packages or hold back the kernel updates and then it was very stable - more than now.
You can try to disable some of the preinstalled and enabled Zorin extensions for testing .
With extension manager you can disable them at tab "installed".
You can install the extension manager with
sudo apt install gnome-shell-extension-manager
Since I test it with disabled gnome extensions except for Zorin taskbar and Zorin menu I had for 4 days no more session crashes in my live session with Zorin 18 boot stick. Before the gnome session crashed nearly every day, especially after suspend, in the last month.
It's a shame not to have all the helpful features, of course, but personally I find the completely unpredictable crashes worse (damaging my usb boot stick and computer because I have to make a hard shutdown then).
You could then gradually re-enable individual extensions to see if the system still works.
Hopefully there will be a solution for this crashes soon!
The Zorin appindicators are reported to make problems (read in few post of other users). I would disable it. If you need this function try it with the gnome extension "AppIndicator and KStatusNotifier" instead.
This white screen of death usually happens because of a GNOME + NVIDIA driver issue when the screen wakes up. Try disabling screen blanking/lock, switching to Xorg instead of Wayland, or updating/downgrading the NVIDIA driver. That often fixes this problem on Zorin and Ubuntu-based systems.