I finally fixed two bugs which i had in my zorin Setup:
https://forum.zorin.com/t/usb-hub-does-not-work-properly
https://forum.zorin.com/t/multiple-monitors-with-different-resolutions-cause-problems-in-full-screen
Please add these two fixes into the Zorin Builds so new users can benefit from this.
USB Hub not working FIX:
sudo apt install libusb-dev
Fractional Scaling with Multi-Monitor Setup with different Resolutions:
Install this GNOME Extension from Github and enable it in Firefox on Gnome extension website: GitHub - kazysmaster/gnome-shell-extension-disable-unredirect