When I enter fullscreen (eg. YouTube, Twitch, X) my monitors are flashing (becoming black and then getting video again).
Does anyone have an idea what the reason for that is?
Are you using Wayland? Try switch to X11 (xorg) when you log in to your account.
Hmm, at least I didn't intentionally change anything here. Where can I see what I am using? I didn't know that Wayland is even available for Gnome in Ubtunu 22.04 LTS 
.
EDIT: No, seems I don't use Wayland:
It may be video card driver related (a guess),
sudo apt install inxi
inxi -Ga
Try driver 545 instead and see if the problem persist.
edit, wrong numbers 
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Interesting, isn't that a way older driver? Are newer NVIDIA drivers for Linux sometimes worse? From what I understand, they are official or not?
EDIT: Ah, 545, not 454 
Newer doesn't always mean better. A lot of bugs was introduced in driver 550. They are still official driver.
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Can you tell me what the best way for Zorin OS is to install a different NVIDIA driver? I don't want to break anything.
The panel shows me this (though I didn't alter the driver):
The best way is to select the driver from "Software & updates". IF it fails I'll still be here to help you out.
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For some strange reason it tells me Continue using a manually installed driver (added a screenshot to my previous post) while I never interfered with the driver.
okay, try this;
sudo apt remove --purge '^nvidia-.*'
sudo apt install nvidia-driver-545
This will remove the current driver and install 545
If it fails, do;
sudo apt remove --purge '^nvidia-.*'
sudo apt install nvidia-driver-550
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Cool, you were right! With 545, the fullscreen problem is gone.
I also had other strange artifacts (single and multiple horizontal lines) with my Dell G2724D, I hope that is also gone now. These artifacts were only sporadic. Maybe you have an idea or do know the issue? An example:
The Telegram Desktop App tells me this by the way:
It's a bit of a hit'n'miss with Nvidia driver. You could try beta driver 555.
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Annoying 
But better than Intel Iris (or how these on-chip GPUs are labelled). A few years ago I tried that with Zorin OS, but the performance was inferior. While it was all smooth on Windows, on Linux I had bad performance so unfortunately I had to move back to Windows.
The performance with NVIDIA now seems to be great, I'm working now on Zorin OS for more than a week and never used Windows again. It feels like I quit smoking.
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Hmm, now I also get in other important programs such as KiCad the error message hat OpenGL is not available. Do I need to install something aside from the NVIDIA drivers?
What does inxi -Ga say now under driver 545?
Hmmm... seems fine enough. I guess the driver is bit bugged.
IF you are adventurous you could try driver 555:
How to Install NVIDIA 555 Series Driver in Ubuntu via PPA | UbuntuHandbook
Or wait til driver 560 comes out.
I had a similar issue with my Nvidia card. I have two monitors and one was connected with HDMI and the other with DP.
I figured out that Nvidia does not like this (Which is odd since they include only one HDMI Port... geniuses...) and switched to two DP cables, solving the issue.