Yes, I mean... you need the system to work correctly.
Debian is the base for Ubuntu. Ubuntu is the base for both Mint and Zorin OS.
With this clue narrowing things down, it looks like something occurs at the Ubuntu development that affects Distros that use it as a base. Because of this, it seems likely to not be desktop dependent, since Mint does not use the Gnome Desktop. It uses Cinnamon and XFCE.
If this is what you go with, feel free to continue to use this forum for interface customization feedback. That is something that several of us do quite a bit, so we may be able to help you to set things up to your liking. Since Zorin OS Software is free open source, you can even install the Zorin Themes.
I would prefer to see a solution to this issue. Since you are affected, others must be as well. And not just Zorin OS users.
That it initially works tells us that the included drivers and configurations also work, but that something added in interrupts that later. It's a clue, but doesn't nail it down.