Here is what I did when I installed Soulstorm on PlayOnLinux:
a. If output of wine --version is NOT wine-6.0, then do steps 1 & 2 here: NET Framework 4.5.2 - #5 by carmar
b. Install playonlinux using Synaptic.
c. Steps on playonlinux are easy - all buttons & no terminal commands:
i. Click Install button
ii. Click Next 4 times
iii. Enter name of a virtual drive - make up a name
iv. Click Next 2 times
v. Choose either 32 bit or 64 bit - if after installation, the game doesn't work on 32 bit, then try 64 bit and reinstall and try again.
vi. Browse to game installation .exe file and click Ok. The .exe will run just like on Windows and MAKE NOTE OF THE INSTALLATION PATH.
vii. Wait for the .exe to finish running - just like on Windows. Make sure you have unchecked any options to run the game at the end of the install. Some GOG installers tend to have this option.
viii. After the installer is done, the system returns you to the PlayOnLinux menu which asks you if you want to create a shortcut. Select the Browse option (2nd option) on that list and browse to the game executable using Home -> PlayOnLinux's Virtual Drives -> Name you gave the Virtual Drive in step iii -> drive_c -> your game installation folder based on step vi.
ix. PlayOnLinux will create a shortcut on your desktop which you can then double-click to launch your game.
I don't know about anything outside of PlayOnLinux but the above directions are the easiest they'll ever be.